Gestational Trophoblastic Neoplasia: A Retrospective Study of 23 Cases
Rajendra Kumar Tanwar,
Bharti Saxena,
Radha Garg,
Harsh Goyal,
Des Deepak
Issue:
Volume 8, Issue 3, September 2020
Pages:
45-50
Received:
13 July 2020
Accepted:
3 August 2020
Published:
10 August 2020
Abstract: Background – The aim of this study is to analyze the clinicopathological features, diagnosis and appropriate treatment outcome of patients with gestational trophoblastic neoplasia (GTN), a heterogenous group of disorder in a government tertiary care hospital center. Method– This is a retrospective study of 23 patients from 2002-2020 over 18 years. The patients were evaluated on the basis of their age, obstetric history and the treatment received. All the patients were scored according to Modified World Health Organization (WHO) prognostic scoring system as adapted by FIGO Year 2000. Low risk group patients were given injection Methotrexate + Calcium Leucovorin and high risk group were given EMACO regimen. After treatment, the patient follow up was till date or minimum up to 2 years. The response to treatment was evaluated by regular clinical and radiological examination and serum β-hCG level estimation. Results – Three out of 23 patients who relapsed after primary chemotherapy were given second line chemotherapy. All three patients achieved complete remission (CR) after salvage chemotherapy. Thus overall response rate is 100%. Conclusion – Proper diagnosis, close monitoring and follow up with β-hCG value is of utmost importance in the management of GTN, WHO/FIGO scoring should be done and managed with chemotherapy treatment according to the risk assessment.
Abstract: Background – The aim of this study is to analyze the clinicopathological features, diagnosis and appropriate treatment outcome of patients with gestational trophoblastic neoplasia (GTN), a heterogenous group of disorder in a government tertiary care hospital center. Method– This is a retrospective study of 23 patients from 2002-2020 over 18 years. ...
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Effect of AGO2 Depletion on Cell Migration of A172 Brain Cancer Cell
Sujin Kim,
Yoonseo Kim,
Wonse Kim,
Woo Rin Lee
Issue:
Volume 8, Issue 3, September 2020
Pages:
51-56
Received:
7 September 2020
Accepted:
29 September 2020
Published:
16 October 2020
Abstract: AGO2, a protein-coding and miRNA regulating gene, has recently been identified as a phenomenal biomarker in cancer development research. Its role varies in different cancers, acting as either a tumor suppressor or an oncogene. However, no research has been conducted on the correlation between AGO2 and brain cancer yet. The aim of this study was to define the association of AGO2 amplification and brain cancer patient’s survival and to investigate the functional role of AGO2 in brain cancer cell migration. 20 brain cancer studies with a total of 6164 patient samples via cBioPortal were analyzed. After the patients were divided into two groups: AGO2 amplified group and AGO2 non-amplified group, the overall patients’ survival rate was analyzed by Kaplan-Meier. The positive correlation between the AGO2 amplified group and survival rates was discovered. To find out how AGO2 amplification increased patients’ survival rates, we performed an in vitro assay to silence AGO2 expression using two siRNAs targeting AGO2 in A172 brain cancer cell line. The wound-healing assay was performed to show that both siRNAs targeting AGO2 promoted cell migration of A172. Therefore, AGO2 may function as a tumor suppressor and enhances survival rates of brain cancer patients by inhibiting cancer cell migration. Further investigation of the mechanisms affecting AGO2 dysregulation will provide insights into the molecular differences underpinning brain cancer patient’s survival rate.
Abstract: AGO2, a protein-coding and miRNA regulating gene, has recently been identified as a phenomenal biomarker in cancer development research. Its role varies in different cancers, acting as either a tumor suppressor or an oncogene. However, no research has been conducted on the correlation between AGO2 and brain cancer yet. The aim of this study was to ...
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