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Research Article |

Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma

The Helicobacter infection was caused many diseases, and found in the liver tissue of primary liver cancer patients. Liver cancer was seriously dangerous of healthy, it confirmed that the correlation between liver cancer and multiple viruses, such as HBV and HCV, even include helicobacter. In this study, we explored the association between helicobacter and primary liver carcinoma. by searching relevant literature with database. The separated case-control studies on relationship between helicobacter infection and primary liver carcinoma were analyzed by Meta-analysis with Revman 5.0. 9 studies were included in the final analysis. Overall the prevalence of helicobacter infection was 52.53% (166 of 316) in case group vs 9.96% (23 of 231) in control group, and the summary odds ratio for the association of helicobacter infection with the risk for primary liver carcinoma (using the fixed-effects model, which accounted for the homogeneity across the 9 studies) was determined to be odds ratio 14.19 (95% CI, 7.92~15.14). Sensitivity analysis showed the results were no publication bias.the funnel plot was approximately standard symmetric, Failure safety number (Nfs) analysis: Calculate Nfs at P=0.05 level, Nfs 0.05=( Σ Z/1.64) 2-K=369.395, the large Nfs value also indicateed that there was no publication bias in the study. So the Meta-analysis demonstrated there was a positive association between helicobacter infection and the risk of primary liver carcinoma.

Helicobacter, Primary Liver Cancer, Meta Analysis

APA Style

Xiaolong, L., Changhe, C. (2024). Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma. Cancer Research Journal, 12(1), 1-4. https://doi.org/10.11648/j.crj.20241201.11

ACS Style

Xiaolong, L.; Changhe, C. Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma. Cancer Res. J. 2024, 12(1), 1-4. doi: 10.11648/j.crj.20241201.11

AMA Style

Xiaolong L, Changhe C. Meta-Analysis on Relation Between Helicobacter Infection and Primary Liver Carcinoma. Cancer Res J. 2024;12(1):1-4. doi: 10.11648/j.crj.20241201.11

Copyright © 2024 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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