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Review Article |

Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone

Giant Cell Tumor of Bone (GCTB) is a common intermediate tumor, and the specific molecular mechanisms of this disease have not been fully elucidated. It exhibits strong heterogeneity in terms of targets, regulatory mechanisms, cell types, states, and subset distributions in the immune microenvironment. Traditional collective-level analyses cannot accurately reveal these differences. Single-cell sequencing technology is a technique that sequences the genome, transcriptome, and epigenome of diseases at the single-cell level. Single-cell sequencing can utilize a higher pixel resolution to reveal characteristic states of different cell subpopulations, contributing to broadening new perspectives for the study of GCTB heterogeneity. It holds significant value for the precise diagnosis of GCTB, identification of potential immunotherapy targets, and prognosis assessment. This study primarily reviews research related to GCTB, single-cell high-throughput sequencing technology, GCTB immune microenvironment, GCTB heterogeneity, and the construction of GCTB cell maps. It aims to provide theoretical reference for research on single-cell sequencing technology in GCTB and offers a theoretical basis for in-depth exploration of the mechanisms and treatment of GCTB.

Giant Cell Tumor of Bone, Single-Cell Sequencing, Tumor Microenvironment, Heterogeneity

APA Style

Liu, Y., Ye, D. (2024). Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone. Cancer Research Journal, 12(1), 5-9.

ACS Style

Liu, Y.; Ye, D. Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone. Cancer Res. J. 2024, 12(1), 5-9. doi: 10.11648/j.crj.20241201.12

AMA Style

Liu Y, Ye D. Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone. Cancer Res J. 2024;12(1):5-9. doi: 10.11648/j.crj.20241201.12

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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