Volume 3, Issue 5, September 2015, Page: 100-103
Histop Athological Comparision of Mast Cell Density in Various Grades of Mucoepidermoid Carcinoma
Farzad Yazdani, Amir Alam Hospital Tehtran University of Medical Sciences, Tehran, Iran
Gita Rezvani, Shahed University, Dentistry School, Tehran, Iran
Sajad Safari, Shahed University, Dentistry School, Tehran, Iran
Maryam Jaberi, Tehran University of Medical School, Tehran, Iran
Received: Jul. 22, 2015;       Accepted: Aug. 7, 2015;       Published: Aug. 21, 2015
DOI: 10.11648/j.crj.20150305.12      View  4048      Downloads  105
Abstract
Mucoepidermoid carcinoma (MEC) is one of most prevalent carcinomas of salivary glands in which the histoathological grading is very important in treatment and prognosis. In this study we are going to compare mast cell density in different kinds of mucoepidermoid grading by Toluidine blue staining. Materials and Methods. Paraffin blocks of 19 cases of low grade and 21 cases of high grade mucoepidermoid carcinoma were selected and stained by toluidine blue.The number of mast cells were observed in two manners(absolute and ordinal).T student was used for absolute counting and Mann Whitney for ordinal counting. in absolute counting,we defined a number for counting, for ordinal counting, we defined an interval range for mast cell numbers. Results. In absolute Counting,the mean of mast cell density in low grade cases was 19.7+/-15.7and in high grade cases was 20.3+/-21.07and there was no significant difference between two groups(p=0.920). In ordinal counting, there was no significant difference between two groups in mast cell density(p=0.729). Conclusion. According to this study, the mast cell counting can not be used for histopathological grading of MEC
Keywords
Mast Cell, Histopathological Grading, Mucoepidermoid Carcinoma
To cite this article
Farzad Yazdani, Gita Rezvani, Sajad Safari, Maryam Jaberi, Histop Athological Comparision of Mast Cell Density in Various Grades of Mucoepidermoid Carcinoma, Cancer Research Journal. Vol. 3, No. 5, 2015, pp. 100-103. doi: 10.11648/j.crj.20150305.12
Reference
[1]
Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology. 3rd ed., Missouri: Saunders Elsevier; 2009 p.
[2]
Regezi JA, Scuibba JJ, Jordan RCK. Oral Pathology: clinical Pathology correlation. 5th ed., Missouri: Sunders Elsevier; 2008. P.203-207
[3]
Seethala RR. An Update on Grading of salivary Gland Carcinomas. Head Neck Pathol. 2009;3(1): 69-77.
[4]
Majidi A. Evaluation of mast cell density in differential diagnosis of Enchondroma and high grade chondrosarcoma. [Doctorate Thesis]. Iran. Dental school of Shahed University; 2009. (Persian)
[5]
Seethala RR. Histologic Grading and Prognostic Biomarkers in Salivary Gland Carcinomas. Adv Anat Pathol. 2011;18(1):29-45
[6]
Kumar V, Abul Abbas K, Fausto N, Mithhell R. Robbins Basic Pathology. 8th Ed, Kenedy: Saunders Elsevier; 2007p.
[7]
Etemad-Moghadam Sh, Gholamhosseini A, Khorshidian A, Alaeddini M. Compasison of mast cell density in hitologic differentiation of oral squamous cell carcinoma based on three different valid grading systems j Isfahan Dent Sch 2014;9(6):509-17
[8]
Aolci M, Pawanckar R, Niimi Y: Masst cell in basal cell carcinoma express VEGF, IL-8 and RANTES. Int Arch Allergy Immunol 2003; 130: 216-223
[9]
Parizi AC, Barbosa RL, Parizi JL, Nai GA. A comparison between the concentration of mast cell in scc of the skin and oral catity. An Bras Dematol 2010 Nov-Dec; 85(6):811-8.
[10]
Mohtasham N, Babakoohi S, Salehinejad J, MontaserKouhsariL, Shakeri MT, Shojaee S et al. Mast cell density and angiogenesis in oral dysplastic epithelium and low and high grade oral squamous cell carcinoma. Acta Odontol Scand 2010;68:300-304.
[11]
Vidal MI, de Oliveria Araujo IB, Gurgel CA, Pereira Fde A, vilas-Boas Ds, Ramos EA, et al. tumor Biol. 2013;34(1):309-16.Density of mast cells and microvessels in minor salivary gland tumors.
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