Volume 7, Issue 3, September 2019, Page: 117-124
High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A Meta-analysis
Fulun Li, Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China
Ke Liu, School of Applied Chemical Engineering, Lanzhou Petrochemical Polytechnic, Lanzhou, China
Qianlong Zhao, Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China
Junyi Chen, Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China
Lingfei Liu, School of Public Health, Lanzhou University, Laanzhou, China
Qing-Mu Xie, Department of Psychology, Tohoku University, Sendai, Japan
Jing Yang, Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China
Received: Aug. 27, 2019;       Accepted: Sep. 10, 2019;       Published: Sep. 24, 2019
DOI: 10.11648/j.crj.20190703.16      View  35      Downloads  8
Abstract
There are many researches on the correlation between C-reactive protein (CRP) and prognosis of gastric cancer, but whether CRP could be used as an evaluation indicator for prognosis of gastric cancer patients, which was still controversial. Therefore, we conducted meta-analysis based on 18 studies involving 3656 objects. The results show that, CRP was significantly correlated with the risk of poor prognosis of gastric cancer patients [HR (95%CI) 1.50 (1.24, 1.81) P=0.000], and the risk of the poor prognosis can be significantly increased when CRP>10mg/L. In the different clinical stage, high expression of CRP can increases the risk of poor prognosis. The CRP can be used as an important indicator of poor prognosis of gastric cancer patients.
Keywords
C-reactive Protein, Gastric Cancer, Prognosis, Meta-analysis
To cite this article
Fulun Li, Ke Liu, Qianlong Zhao, Junyi Chen, Lingfei Liu, Qing-Mu Xie, Jing Yang, High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A Meta-analysis, Cancer Research Journal. Vol. 7, No. 3, 2019, pp. 117-124. doi: 10.11648/j.crj.20190703.16
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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