Volume 7, Issue 4, December 2019, Page: 129-135
Dosimetric Evaluation of TF-3DCRT, FIF-Forward IMRT and FF Inversely Optimized IMRT for Breast Conserving Treatment
Duan Yunlong, Radiotherapy Centre, Gansu Province Wuwei Tumor Hospital, Wuwei, China; Radiotherapy Department, PLA General Hospital, Beijing, China
Wang Xiaopeng, Radiotherapy Centre, Gansu Province Wuwei Tumor Hospital, Wuwei, China
Yang Tao, Radiotherapy Department, PLA General Hospital, Beijing, China
Qu Baolin, Radiotherapy Department, PLA General Hospital, Beijing, China
Cai Boning, Radiotherapy Department, PLA General Hospital, Beijing, China
Dai Xiangkun, Radiotherapy Department, PLA General Hospital, Beijing, China
Ge Ruigang, Radiotherapy Department, PLA General Hospital, Beijing, China
Xu Wei, Radiotherapy Department, PLA General Hospital, Beijing, China
Xu Shouping, Radiotherapy Department, PLA General Hospital, Beijing, China
Received: Aug. 4, 2019;       Accepted: Aug. 29, 2019;       Published: Oct. 9, 2019
DOI: 10.11648/j.crj.20190704.12      View  41      Downloads  9
Abstract
Objective: To compare the dosimetric characteristic of tangential field 3D conformal (TF-3DCRT, TF), field-in-field intensity-modulated (FIF-IMRT, FIF) and fixed-field inversely optimized intensity-modulated Radiotherapy (FFIO-IMRT, FFIO) for breast conserving treatment, and explore the benefit and efficiency for the three techniques. Materials and Methods: TF-3DCRT, FIF-IMRT and FFIO-IMRT treatment plans were analyzed for 16 breast patients (8 right-sided and 8 left-sided) after breast-conserving surgery. The target and organs at risk (OARs) were contoured by the same physician in the CT images. The prescription dose was 50Gy/25f. TF-3DCRT and FIF-IMRT were designed using Varian Eclipse Ver10.0 planning system, and FFIO-IMRT in the planning system of Pinnacle Ver9.6. Treatment plans were compared according to dose volume histogram (DVH) analysis in terms of PTV homogeneity and conformity indices (HI and CI) as well as OARs dose and volume parameters, and the efficiency was also evaluated. Results: In all cases, the treatment plans showed statistically significant difference between TF-3DCRT, FIF and FFIO-IMRT. The MUs were 244.9±8.3MU vs 285.9±20.3MU vs 534.0±56.2MU (p<0.001), the CIs of dose distribution and the target were 0.40±0.12 vs 0.48±0.12 vs 0.57±0.12 (p<0.01), and the HIs were 0.20±0.02 vs 0.13±0.02 vs 0.17±0.02 (p<0.01). Compared with TF and FFIO, FIF-IMRT showed smaller in the dose of D2 and volume of V107 and V110 in the target. FFIO-IMRT generally increased the D mean, V10 and V20 of ipsilateral lung, the D1 of contralateral breast and the mean dose of contralateral lung, heart, esophagus, and spinal cord relative to TF and FIF techniques. Conclusion: In breast-conserving RT, FIF-IMRT improved the overall quality of dose distribution and delivery efficiency, and the patients are most likely to benefit from FIF-IMRT.
Keywords
Breast Cancer, Tangential Field, 3DCRT, IMRT, Dosimetry
To cite this article
Duan Yunlong, Wang Xiaopeng, Yang Tao, Qu Baolin, Cai Boning, Dai Xiangkun, Ge Ruigang, Xu Wei, Xu Shouping, Dosimetric Evaluation of TF-3DCRT, FIF-Forward IMRT and FF Inversely Optimized IMRT for Breast Conserving Treatment, Cancer Research Journal. Vol. 7, No. 4, 2019, pp. 129-135. doi: 10.11648/j.crj.20190704.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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