Volume 8, Issue 2, June 2020, Page: 20-25
Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique
Md. Zillur Rahman Bhuiyan, Department of Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mamun Or Rashid, Department of Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Sadia Sharmin, Department of Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Moshiur Rahman, Department of Radiation Oncology, National Institute of Cancer Research Hospital, Dhaka, Bangladesh
Received: Jan. 4, 2020;       Accepted: Mar. 19, 2020;       Published: Apr. 23, 2020
DOI: 10.11648/j.crj.20200802.11      View  132      Downloads  64
Abstract
Background: According to the global World Health Organization statistics, about 7.9 million deaths occur each year due to cancer. Of these death about 70% occurring in developing countries. Cancer of the cervix is the eight most common cancer in women in the world. Bangladesh has the highest level of incidence and mortality rates due to cervical cancer among women. Methods: In this prospective observational study total 60 number of subjects were enrolled to compare the effectiveness of external beam radiation therapy by four field box technique versus two field technique in the treatment of locally advanced carcinoma of uterine cervix. Clinically and histologically diagnosed squamous cell carcinoma of uterine cervix patients were selected as study population. Results: In this study the highest number of patients were in between 46 to 55 years. Majority of the patients were from poor socio-economic class and most were illiterate. Most of the subject used Oral contraceptive pill more than 5 years. Most of the patients were in stage IIB. Most of the patients were presented with postcoital bleeding, anemia, vaginal discharge, loss of appetite, Intermenstrual bleeding and pelvic pain. After completion of treatment follow-up per vaginal examination revealed that 73.33% subjects had complete response in four field group (Arm A). In two field group (Arm B), 56.66% had complete response. Common toxicities related to treatment were nausea, vomiting, diarrhea, skin reaction, anemia, leucopenia, bladder toxicity and rectal toxicity. Conclusion: From this study it can be concluded that four field box technique in EBRT was statistically effective in relieving symptoms and achieving complete response than two field technique in the treatment of locally advanced carcinoma of uterine cervix.
Keywords
CCRT (Concurrent Chemo-Radiation), EBRT (External Beam Radiation Therapy), RT (Radiotherapy), BT (Brachytherapy)
To cite this article
Md. Zillur Rahman Bhuiyan, Mamun Or Rashid, Sadia Sharmin, Moshiur Rahman, Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique, Cancer Research Journal. Vol. 8, No. 2, 2020, pp. 20-25. doi: 10.11648/j.crj.20200802.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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