Volume 8, Issue 2, June 2020, Page: 26-35
Clinical Characteristics and Outcome of Infantile Fibrosarcoma: A Retrospective Single-institution Review
Enas El Nadi, Department of Clinical Oncology, Faculty of Medicine, Beni - Suef University, Beni-Suef, Egypt; Department of Pediatric Oncology, Children Cancer Hospital of Egypt (CCHE) Cairo, Egypt
Mona Moustafa, Department of Pediatric Oncology, Children Cancer Hospital of Egypt (CCHE) Cairo, Egypt
Gehad Ahmed, Department of Surgery, Faculty of Medicine, Helwan University, Helwan, Egypt; Department of Surgical Oncology, Children Cancer Hospital of Egypt (CCHE) Cairo, Egypt
Alaa Younes, Department of Surgical Oncology, Children Cancer Hospital of Egypt (CCHE) Cairo, Egypt; Department of Surgical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
Mohamed Saad Zaghloul, Department of Radiotherapy, National Cancer Institute, Cairo University, Cairo, Egypt; Department of Radiotherapy, Children Cancer Hospital of Egypt (CCHE) Cairo, Egypt
Naglaa ElKinaai, Department of Surgical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt; Department of Surgical Pathology, Children Cancer Hospital of Egypt (CCHE) Cairo, Egypt
Amal Rafaat, Department of Radiodiagnosis, National Cancer Institute, Cairo University, Cairo, Egypt; Department of Radiodiagnosis, Children Cancer Hospital of Egypt (CCHE), Cairo, Egypt
Elham Khaled, Department of Clinical Research Children Cancer Hospital of Egypt (CCHE), Cairo, Egypt
Sayed Abdel Hamid, Department of Pediatric Oncology, Children Cancer Hospital of Egypt (CCHE) Cairo, Egypt; Department of Pediatric Hematology/Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
Received: Mar. 18, 2020;       Accepted: Apr. 9, 2020;       Published: Apr. 28, 2020
DOI: 10.11648/j.crj.20200802.12      View  401      Downloads  130
Abstract
Analysis was done to the clinical characteristics and outcome of children with infantile Fibrosarcoma (IFS) who were treated at Children’s Cancer Hospital Egypt (CCHE). A Retrospective chart review of all pathologically confirmed IFS patients treated at CCHE from July 2011 till December 2016. Detailed demographic, pathological, and clinical data of 27 IFS patients were collected, analyzed and correlated with treatment outcome and survival. We enrolled 27 patients with a median age 0.23 years (range 0.03-3.8), 54% were females. Extremities were the commonest primary site (59.3%), followed by head and neck (22.2%). The tumor size was >5cm in 18 patients, <5cm in six and undetermined in three. It was resectable without preoperative chemotherapy in three patients. Twenty one received preoperative VAC (Vincristine, Actinomycin-D and Cyclophosphamide) of those nine cases received second line Ifosphamide and Adriamycin to improve respectability. Overall survival of the whole group of patients was 82.3%. We need to increase sample size and to get facility for proper diagnosis by genetic analysis in such difficult cases for better pathological diagnosis
Keywords
Infantile Fibrosarcoma, Risk Factors, Survival
To cite this article
Enas El Nadi, Mona Moustafa, Gehad Ahmed, Alaa Younes, Mohamed Saad Zaghloul, Naglaa ElKinaai, Amal Rafaat, Elham Khaled, Sayed Abdel Hamid, Clinical Characteristics and Outcome of Infantile Fibrosarcoma: A Retrospective Single-institution Review, Cancer Research Journal. Vol. 8, No. 2, 2020, pp. 26-35. doi: 10.11648/j.crj.20200802.12
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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