Volume 8, Issue 2, June 2020, Page: 36-41
Factors Affecting Survival in Egyptian Patients with Advanced Vulval Cancer
Ahmed Aly Nagy, Department of Clinical Oncology, Ain Shams University, Cairo, Egypt
Ahmed Nader, Department of Clinical Oncology, Ain Shams University, Cairo, Egypt
Received: May 9, 2020;       Accepted: May 27, 2020;       Published: Jun. 8, 2020
DOI: 10.11648/j.crj.20200802.13      View  323      Downloads  94
INTRODUCTION: Vulvar carcinoma accounts for about 4% of the female reproductive tract cancers and a total of 0.6% of all malignant cancers in females. PATIENTS AND METHODS: This retrospective study aimed to identify the possible risk factors which can impact survival in Egyptian patients with vulval cancer who received treatment at Ain Shams University department of clinical oncology and nuclear medicine in the period from 1-1-2007 till 1-1-2012. RESULTS: Our study included 64 patients [median age 63 years, median overall survival (OS) was 16.5 months]. The factors associated with favourable impact on OS were: Rural residence (17 versus 10 months for patients from urban residence, p=0.002), premenopausal status (19 versus 16 months in post menopausal patients, p<0.001), low grade histology (19 versus 10 months in patients with high grade, p<0.001) and negative resection margins (19 versus 10 months in case of positive margin, p<0.001). The factors associated with poor OS were: higher number of offspring (≥5 offspring, OS 10 versus 19 months if less than 5 offspring, p<0.001), patients presenting with ulcer rather than mass (11 versus 19 months, p<0.001 and those with bilateral disease (10 versus 17 months in unilateral disease, p=0.04), presence of ≥4 positive groin lymph nodes metastases (OS =16 months versus 17 months, p=0.047) tumor size ≥ 4 cm (10 versus 17 months in case of <4 cm, p=0.001) and depth of stromal invasion (17 versus 16 months in case of <1 cm and ≥ 1 cm respectively, p=0.015) CONCLUSION: Urbanization has been linked with more aggressive disease leading to decrease of OS. The age of onset of intercourse did not affect survival as was expected however multiple offspring which could be related to more frequent intercourse had an effect on survival. The offered treatment modalities did not show a superiority probably because all the patients presented in an advanced stage. The anatomical nature of this cancer might be the cause in delayed diagnosis which warrants health education projects for early detection. Further studies are required to assess the risk factors for development of vulval cancer in Egyptian patients.
Vulva, Cancer, Retrospective
To cite this article
Ahmed Aly Nagy, Ahmed Nader, Factors Affecting Survival in Egyptian Patients with Advanced Vulval Cancer, Cancer Research Journal. Vol. 8, No. 2, 2020, pp. 36-41. doi: 10.11648/j.crj.20200802.13
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