Volume 8, Issue 2, June 2020, Page: 42-44
Acute Lymphoblastic Leukemia with Primary Testicular Involvement in a Pre-pubertal Male: A Case Report
Patrick Olanrewaju Osho, Department of Haematology & Blood Transfusion, Faculty of Basic Clinical Sciences, University of Medical Sciences, Ondo-City, Nigeria
Matilda Adesuwa Osagie Ojo, Department of Haematology & Blood Transfusion, Faculty of Basic Clinical Sciences, University of Medical Sciences, Ondo-City, Nigeria
Eevenly Salawa Osho, Department of Radiology, Faculty of Basic Clinical Sciences, University of Medical Sciences, Ondo-City, Nigeria
Olufunke Caroline Odunlade, Department of Paediatrics, Faculty of Clinical Sciences, University of Medical Sciences, Ondo-City, Nigeria
Oluwatosin Idowu Oni, Department of Haematology/Virology, University of Medical Sciences Teaching Hospital, Akure, Nigeria
Received: May 22, 2020;       Accepted: Jun. 10, 2020;       Published: Jul. 4, 2020
DOI: 10.11648/j.crj.20200802.14      View  72      Downloads  36
Abstract
Acute lymphoblastic leukaemia is the most common malignancy in paediatric patients; its diagnosis is usually easy to establish as malignant lymphoblasts invade the bone marrow and peripheral blood. Patients with Acute lymphoblastic leukaemia (ALL) may initially present with pancytopenia and a hypoplastic or hyperplastic bone marrow. Fever is common at presentation, and despite neutropenia, sepsis is rarely seen. Other common clinical manifestations include fatigue, pallor, petechiae, bleeding, lymphadenopathy and hepatosplenomegaly. Presentation with primarily testicular disease is exceedingly rare in acute lymphoblastic leukemia. The unusual presentation of a primary left testicular involvement in ALL is being highlighted in this case report. We present an 11 year old boy who presented with fever, generalized body pain, abdominal discomfort as well as left testicular swelling. Bone marrow studies, Full blood count and peripheral blood film appearance were typical of acute lymphoblastic leukaemia. Ultrasound findings showed left scrotal enlargement with reduced and coarse parenchymal echotexture, while cytogenetic studies revealed positive Philadelphia chromosomes. There was good response to standard ALL therapy. Clinical remission with normal left testicular size was noted at the end of induction phase of therapy.
Keywords
Acute Lymphoblastic Leukemia, Positive Philadelphia Chromosomes, Left Testicular Enlargement
To cite this article
Patrick Olanrewaju Osho, Matilda Adesuwa Osagie Ojo, Eevenly Salawa Osho, Olufunke Caroline Odunlade, Oluwatosin Idowu Oni, Acute Lymphoblastic Leukemia with Primary Testicular Involvement in a Pre-pubertal Male: A Case Report, Cancer Research Journal. Vol. 8, No. 2, 2020, pp. 42-44. doi: 10.11648/j.crj.20200802.14
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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