Volume 8, Issue 4, December 2020, Page: 57-61
Malignant Ovarian Germ Cell Tumors in Pediatric Age Group: A Clinicopathological Study over 21 Years in Eastern Rajasthan (India)
Rajendra Kumar Tanwar, Department of Radiation Oncology, Government Medical College, Kota, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India
Bharti Saxena, Deaprtment of Obstetrics and Gynaecology, Government Medical College, Kota, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India
Shankar Lal Mohanpuria, Deaprtment of Obstetrics and Gynaecology, Government Medical College, Kota, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India
Harsh Goyal, Department of Radiation Oncology, Government Medical College, Kota, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India
Laxmi Agarwal, Department of Pathology, Pushpadi Cancer Care Centre, Kota, Rajasthan, India
Madhu Saxena, Deaprtment of Anaesthesiology, Government Medical College, Kota, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India
Man Mohan Agarwal, Department of Surgical Oncology, Pushpadi Cancer Care Centre, Kota, Rajasthan, India
Received: Aug. 18, 2020;       Accepted: Sep. 3, 2020;       Published: Oct. 27, 2020
DOI: 10.11648/j.crj.20200804.11      View  61      Downloads  26
Abstract
Background: The aim of this study is to analyze the clinicopathological features, diagnosis and treatment outcome of rare cases of malignant ovarian germ cell tumors in a government tertiary care hospital centre keeping fertility preservation surgery as a goal in young girls below 21 years of age. Methods: This is a retrospective study comprising of 24 patients diagnosed to have malignant ovarian germ cell tumors who attend the department of Radiation Oncology from 1998 to 2019 over 21 years period. The patients were evaluated on the basis of their age, obstetric history, investigations, and serum tumor markers estimation. All patients were staged according to FIGO, ECOG score were noted. Unilateral Salphingo oophorectomy (USO) with or without staging laparotomy surgery was done and BEP chemotherapy regimen was given. Response to treatment was evaluated by regular clinical examination, radiological and tumor marker studies. Results: In our study 17 patients were in FIGO stage III and 6 patients were in stage IV. The size of the primary tumor was 10-20 cm. in 15 patients. The various histology observed was-dysgerminoma -8, malignant teratoma-5, mixed germ cell tumor-5, yok sac tumor-4 and embryonal carcinoma in 2 patients. Eighteen patients underwent fertility preservation surgery i.e. USO - 15, and 3 patients underwent USO with staging laparotomy. In 14 patients 3-4 cycles of adjuvant chemotherapy (BEP regimen) was administered and all of them achieved complete remission. Conclusion: Malignant ovarian germ cell tumors carries excellent prognosis in spite of advanced stage disease. Patients should be referred to oncology centre and to be operated by gynecologic oncologist/ oncosurgeon. Adjuvant chemotherapy should be given to achieve complete remission.
Keywords
Germ Cell Tumor Ovary, Fertility Preserving Surgery, Neo-adjuvant Chemotherapy, BEP Regimen
To cite this article
Rajendra Kumar Tanwar, Bharti Saxena, Shankar Lal Mohanpuria, Harsh Goyal, Laxmi Agarwal, Madhu Saxena, Man Mohan Agarwal, Malignant Ovarian Germ Cell Tumors in Pediatric Age Group: A Clinicopathological Study over 21 Years in Eastern Rajasthan (India), Cancer Research Journal. Vol. 8, No. 4, 2020, pp. 57-61. doi: 10.11648/j.crj.20200804.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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