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Research Article |

IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia

Background: Interleukin-17 (IL-17) is a cytokine pivotal in inflammation, autoimmune disorders, and cancer. This cytokine family comprises six members, including IL-17A to IL-17F, and five receptors, namely IL-17RA to IL-17RD and SEF. Several clinical studies have shown an increased expression of IL-17 in neoplastic disorders. Additionally, single nucleotide polymorphisms (SNPs) can impact gene functions and protein expression, which can in turn affect cellular proliferation and ultimately increase the risk of developing cancer. IL17F rs763780 gene polymorphism is linked to an increased risk of several malignancies and immunological disorders. The present study investigated the association between IL17F rs763780 gene polymorphism and susceptibility, clinicopathological features, and prognosis in adult Egyptian patients with AML. Patients and method: 102 AML patients (68 males and 34 females) and 106 healthy individuals were genotyped for the IL17F rs763780 gene using a polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) assay. Results: Homozygous mutant GG genotype and G allele were significantly higher in AML patients than in the healthy control. However, no significant correlation was found between the gene polymorphism and disease characteristics or prognosis in different genotypes. Conclusion: mutant genotypes and alleles of the IL17F rs763780 gene polymorphism may be associated with an increased risk of AML among Egyptian patients.

AML, IL17F rs763780, Prognosis

APA Style

Elderiny, W. E., Ebrahim, M. A., Ramez, A. M., Taalab, M. M. (2024). IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia. Cancer Research Journal, 12(1), 10-15.

ACS Style

Elderiny, W. E.; Ebrahim, M. A.; Ramez, A. M.; Taalab, M. M. IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia. Cancer Res. J. 2024, 12(1), 10-15. doi: 10.11648/crj.20241201.13

AMA Style

Elderiny WE, Ebrahim MA, Ramez AM, Taalab MM. IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia. Cancer Res J. 2024;12(1):10-15. doi: 10.11648/crj.20241201.13

Copyright © 2024 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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