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Research Article |

IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia

Background: Interleukin-17 (IL-17) is a cytokine pivotal in inflammation, autoimmune disorders, and cancer. This cytokine family comprises six members, including IL-17A to IL-17F, and five receptors, namely IL-17RA to IL-17RD and SEF. Several clinical studies have shown an increased expression of IL-17 in neoplastic disorders. Additionally, single nucleotide polymorphisms (SNPs) can impact gene functions and protein expression, which can in turn affect cellular proliferation and ultimately increase the risk of developing cancer. IL17F rs763780 gene polymorphism is linked to an increased risk of several malignancies and immunological disorders. The present study investigated the association between IL17F rs763780 gene polymorphism and susceptibility, clinicopathological features, and prognosis in adult Egyptian patients with AML. Patients and method: 102 AML patients (68 males and 34 females) and 106 healthy individuals were genotyped for the IL17F rs763780 gene using a polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) assay. Results: Homozygous mutant GG genotype and G allele were significantly higher in AML patients than in the healthy control. However, no significant correlation was found between the gene polymorphism and disease characteristics or prognosis in different genotypes. Conclusion: mutant genotypes and alleles of the IL17F rs763780 gene polymorphism may be associated with an increased risk of AML among Egyptian patients.

AML, IL17F rs763780, Prognosis

APA Style

Elderiny, W. E., Ebrahim, M. A., Ramez, A. M., Taalab, M. M. (2024). IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia. Cancer Research Journal, 12(1), 10-15. https://doi.org/10.11648/crj.20241201.13

ACS Style

Elderiny, W. E.; Ebrahim, M. A.; Ramez, A. M.; Taalab, M. M. IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia. Cancer Res. J. 2024, 12(1), 10-15. doi: 10.11648/crj.20241201.13

AMA Style

Elderiny WE, Ebrahim MA, Ramez AM, Taalab MM. IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia. Cancer Res J. 2024;12(1):10-15. doi: 10.11648/crj.20241201.13

Copyright © 2024 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. Kadia TM, Ravandi F, Cortes J, Kantarjian H. Toward Individualized Therapy in Acute Myeloid Leukemia: A Contemporary Review. JAMA Oncol. 2015; 1(6): 820–828. doi: 10.1001/jamaoncol.2015.0617. PMID: 26181162.
2. Lion E, Willemen Y, Berneman ZN, Van Tendeloo VF, Smits EL. Natural killer cell immune escape in acute myeloid leukemia. Leukemia. 2012 Sep; 26(9): 2019-26. doi: 10.1038/leu.2012.87. Epub 2012 Mar 26. PMID: 22446501.
3. Shibata T, Tahara T, Hirata I, Arisawa T. Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. Hum Immunol. 2009 Jul; 70(7): 547-51. doi: 10.1016/j.humimm.2009.04.030. Epub 2009 May 3. PMID: 19414056.
4. Moseley TA, Haudenschild DR, Rose L, Reddi AH. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 2003 Apr; 14(2): 155-74. doi: 10.1016/s1359-6101(03)00002-9. PMID: 12651226.
5. Kawaguchi M, Adachi M, Oda N, Kokubu F, Huang SK. IL-17 cytokine family. J Allergy Clin Immunol. 2004 Dec; 114(6): 1265-73. doi: 10.1016/j.jaci.2004.10.019. PMID: 15577820.
6. Iwakura Y, Ishigame H, Saijo S, Nakae S. Functional specialization of interleukin-17 family members. Immunity. 2011 Feb 25; 34(2): 149-62. doi: 10.1016/j.immuni.2011.02.012. PMID: 21349428.
7. Niu YM, Yuan H, Zhou Y. Interleukin-17 gene polymorphisms contribute to cancer risk. Mediators Inflamm. 2014; 2014: 128490. doi: 10.1155/2014/128490. Epub 2014 Jul 24. PMID: 25147431; PMCID: PMC4131465.
8. Ersvær E, Melve GK, Bruserud O. Future perspectives: should Th17 cells be considered as a possible therapeutic target in acute myeloid leukemia patients receiving allogeneic stem cell transplantation? Cancer Immunol Immunother. 2011 Dec; 60(12): 1669-81. doi: 10.1007/s00262-011-1118-z. Epub 2011 Oct 12. PMID: 21989580.
9. Ramsey CD, Lazarus R, Camargo CA, Weiss S, Celedon JC. "Polymorphisms in the interleukin 17F gene (IL17F) and asthma." Genes Immun. 2005 June; 6(3): 236-241. doi: 10.1038/sj.gene.6364170. PMID: 15703761.
10. Kawaguchi M, Takahashi D, Hizawa N, Suzuki S, Matsukura S, Kokubu F, Maeda Y, Fukui Y, Konno S, Huang SK, Nishimura M, Adachi M. IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. J Allergy Clin Immunol. 2006 Apr; 117(4): 795-801. doi: 10.1016/j.jaci.2005.12.1346. Epub 2006 Feb 14. PMID: 16630936.
11. Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, Fujita H, Nakamura M, Yoshioka D, Arima Y, Okubo M, Hirata I, Nakano H. The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis. J Clin Immunol. 2008 Jan; 28(1): 44-9. doi: 10.1007/s10875-007-9125-8. Epub 2007 Sep 9. PMID: 17828618.
12. Qian F, Zhang Q, Zhou L, Ma G, Jin G, Huang Q, Yin K. Association between polymorphisms in IL17F and male asthma in a Chinese population. J Investig Allergol Clin Immunol. 2012; 22(4): 257-63. PMID: 22812194.
13. Wu X, Zeng Z, Chen B, Yu J, Xue L, Hao Y, Chen M, Sung JJ, Hu P. Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. Int J Cancer. 2010 Jul 1; 127(1): 86-92. doi: 10.1002/ijc.25027. PMID: 19904747.
14. Innocenti F, Owzar K, Cox NL, Evans P, Kubo M, Zembutsu H, Jiang C, Hollis D, Mushiroda T, Li L, Friedman P, Wang L, Glubb D, Hurwitz H, Giacomini KM, McLeod HL, Goldberg RM, Schilsky RL, Kindler HL, Nakamura Y, Ratain MJ. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clin Cancer Res. 2012 Jan 15; 18(2): 577-84. doi: 10.1158/1078-0432.CCR-11-1387. Epub 2011 Dec 5. PMID: 22142827; PMCID: PMC3412624.
15. Wang L, Jiang Y, Zhang Y, Wang Y, Huang S, Wang Z, Tian B, Yang Y, Jiang W, Pang D. Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer. PLoS One. 2012; 7(3): e34400. doi: 10.1371/journal.pone.0034400. Epub 2012 Mar 26. PMID: 22461912; PMCID: PMC3312906.
16. Zhou B, Zhang P, Wang Y, Shi S, Zhang K, Liao H, Zhang L. Interleukin-17 gene polymorphisms are associated with bladder cancer in a Chinese Han population. Mol Carcinog. 2013 Nov; 52(11): 871-8. doi: 10.1002/mc.21928. Epub 2012 Jun 12. PMID: 22692973.
17. Omrane I, Baroudi O, Bougatef K, Mezlini A, Abidi A, Medimegh I, Stambouli N, Ayari H, Kourda N, Uhrhammer N, Bignon YJ, Benammar Elgaaied A, Marrakchi R. Significant association between IL23R and IL17F polymorphisms and clinical features of colorectal cancer. Immunol Lett. 2014 Mar-Apr; 158(1-2): 189-94. doi: 10.1016/j.imlet.2014.01.002. Epub 2014 Jan 14. PMID: 24440568.
18. Dai ZM, Zhang TS, Lin S, Zhang WG, Liu J, Cao XM, Li HB, Wang M, Liu XH, Liu K, Li SL, Dai ZJ. Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: an updated meta-analysis. Sci Rep. 2016 Feb 4; 6: 20439. doi: 10.1038/srep20439. PMID: 26843459; PMCID: PMC4740815.
19. Wu C, Wang S, Wang F, Chen Q, Peng S, Zhang Y, Qian J, Jin J, Xu H. Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia. Clin Exp Immunol. 2009 Nov; 158(2): 199-204. doi: 10.1111/j.1365-2249.2009.04011. x. Epub 2009 Aug 11. PMID: 19737137; PMCID: PMC2768809.
20. Abousamra NK, Salah El-Din M, Helal R. Prognostic value of Th17 cells in acute leukemia. Med Oncol. 2013 Dec; 30(4): 732. doi: 10.1007/s12032-013-0732-3. Epub 2013 Oct 2. PMID: 24085544; PMCID: PMC3840286.
21. Yu S, Liu C, Zhang L, Shan B, Tian T, Hu Y, Shao L, Sun Y, Ji C, Ma D. Elevated Th22 cells correlated with Th17 cells in peripheral blood of patients with acute myeloid leukemia. Int J Mol Sci. 2014 Jan 27; 15(2): 1927-45. doi: 10.3390/ijms15021927. PMID: 24473142; PMCID: PMC3958830.
22. Elsissy M, Abdelhafez A, Elmasry M, Salah D. Interleukin-17 Gene Polymorphism Is Protective Against the Susceptibility to Adult Acute Myeloid Leukaemia in Egypt: A Case-Control Study. Open Access Maced J Med Sci. 2019 May 15; 7(9): 1425-1429. doi: 10.3889/oamjms.2019.306. PMID: 31198448; PMCID: PMC6542383.
23. Zayed RA, El-Saadany Z, Raslan HN, Ghareeb M, Ibraheem D, Rashed M, Kandil R, Abdeldayem OY. IL-17 A and IL-17 F single nucleotide polymorphisms and acute myeloid leukemia susceptibility and response to induction therapy in Egypt, Meta Gene. (26) 2020, 100773. doi.org/10.1016/j.mgene.2020.100773.
24. Mahfouz KA, Abo-Nar AA, S. M. Bendary SM. Role of Interleukin17F (IL17F) gene polymorphism in susceptibility to acute myeloid leukemia. J Leuk., 7 (2018), p. 252. DOI: 10.35248/2329-6917.19.7.252.
25. Vardiman JW. The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: an overview with emphasis on the myeloid neoplasms. Chem Biol Interact. 2010 Mar 19; 184(1-2): 16-20. doi: 10.1016/j.cbi.2009.10.009. Epub 2009 Oct 24. PMID: 19857474.
26. Tian T, Yu S, Ma D. Th22 and related cytokines in inflammatory and autoimmune diseases. Expert Opin Ther Targets. 2013 Feb; 17(2): 113-25. doi: 10.1517/14728222.2013.736497. Epub 2012 Dec 21. PMID: 23256771.
27. Cua DJ, Tato CM. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol. 2010 Jul; 10(7): 479-89. doi: 10.1038/nri2800. Epub 2010 Jun 18. Erratum in: Nat Rev Immunol. 2010 Aug; 10(8): 611. Erratum in: Nat Rev Immunol. 2010 Jul; 10(7): following 489. PMID: 20559326.
28. Alexandrakis MG, Pappa CA, Miyakis S, Sfiridaki A, Kafousi M, Alegakis A, Stathopoulos EN. Serum interleukin-17 and its relationship to angiogenic factors in multiple myeloma. Eur J Intern Med. 2006 Oct; 17(6): 412-6. doi: 10.1016/j.ejim.2006.02.012. PMID: 16962948.
29. Zhang B, Rong G, Wei H, Zhang M, Bi J, Ma L, Xue X, Wei G, Liu X, Fang G. The prevalence of Th17 cells in patients with gastric cancer. Biochem Biophys Res Commun. 2008 Sep 26; 374(3): 533-7. doi: 10.1016/j.bbrc.2008.07.060. Epub 2008 Jul 23. PMID: 18655770.
30. Zhu X, Mulcahy LA, Mohammed RA, Lee AH, Franks HA, Kilpatrick L, Yilmazer A, Paish EC, Ellis IO, Patel PM, Jackson AM. IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines. Breast Cancer Res. 2008; 10(6): R95. doi: 10.1186/bcr2195. Epub 2008 Nov 17. PMID: 19014637; PMCID: PMC2656888.
31. Wróbel T, Gębura K, Wysoczańska B, Jaźwiec B, Dobrzyńska O, Mazur G, Kuliczkowski K, Bogunia-Kubik K. IL-17F gene polymorphism is associated with susceptibility to acute myeloid leukemia. J Cancer Res Clin Oncol. 2014 Sep; 140(9): 1551-5. doi: 10.1007/s00432-014-1674-7. Epub 2014 May 3. PMID: 24793548; PMCID: PMC4131129.
32. Tian T, Sun Y, Li M, He N, Yuan C, Yu S, Wang M, Ji C, Ma D. Increased Th22 cells as well as Th17 cells in patients with adult T-cell acute lymphoblastic leukemia. Clin Chim Acta. 2013 Nov 15; 426: 108-13. doi: 10.1016/j.cca.2013.09.014. Epub 2013 Sep 21. PMID: 24064425.
33. Han Y, Ye A, Bi L, Wu J, Yu K, Zhang S. Th17 cells and interleukin-17 increase with poor prognosis in patients with acute myeloid leukemia. Cancer Sci. 2014 Aug; 105(8): 933-42. doi: 10.1111/cas.12459. Epub 2014 Aug 11. PMID: 24890519; PMCID: PMC4317867.