Cancer Research Journal

Volume 9, Issue 2, June 2021

  • Impact of Initial Prognostic Factors and Intensity of Salvage Therapy on the Outcome of Progressive / Refractory High-Risk Neuroblastoma

    Ahmed Elhemaly, Ahmed Fathalla, Mahmed Elhusseny, Mohamed Fawzy

    Issue: Volume 9, Issue 2, June 2021
    Pages: 85-91
    Received: Mar. 13, 2021
    Accepted: Mar. 27, 2021
    Published: Apr. 07, 2021
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    Abstract: Background: High-risk Neuroblastoma (N. B) patients have a poor outcome with 5-year survival rates of 50%. Patients with stage 4 disease or MYC-N amplification showed post-progression 5y O. S. of 7% to 8%. Other studies proved the same dismal outcome in high-risk relapsed patients. This study aimed to detect the O. S. and EFS of N. B patients post-... Show More
  • Risk Factors and Molecular Study of Vimentin Gene (VIM), Associated with Female Breast Cancer in Khartoum, Sudan

    Hala Abdalgader Khairalseed Abas, Hind Abdelaziz Elnasri, Mona Abdelrahman Mohmed Khaier

    Issue: Volume 9, Issue 2, June 2021
    Pages: 92-97
    Received: May 31, 2020
    Accepted: Jul. 04, 2020
    Published: May 08, 2021
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    Abstract: Background: The aim of this study was to investigate the possible risk factors and mutations in VIM gene among Sudanese’s breast cancer women in Khartoum State. Methods: This case-control study involved 45 patients with breast cancer and 45controls. It was conducted across three hospitals and two laboratories in Khartoum State. A structural questio... Show More
  • Outcome of Sentinel Lymph Node Biopsy with Methylene Blue Dye in Early-stage Breast Cancer

    Khandakar A. B. M. Abdullah Al Hasan, A. F. M. Anowar Hossain, Md Ashiqur Rahman, Sabiha Sultana

    Issue: Volume 9, Issue 2, June 2021
    Pages: 98-105
    Received: Apr. 03, 2021
    Accepted: Apr. 21, 2021
    Published: May 14, 2021
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    Abstract: Background: Axillary staging is the standard of care for all breast cancers amenable to curative treatment. Sentinel lymph node biopsy (SLNB) has been established as the gold standard for axillary staging and has supplanted axillary lymph node dissection (ALND) as a means of regional nodal staging in clinically node-negative breast cancer. Differen... Show More
  • Expression of HER2 in Gastric Carcinoma According to Tumor Location

    Monoar Hossain, Miranur Rahman, Mohammad Sahajadul Alam, Monzurul Islam

    Issue: Volume 9, Issue 2, June 2021
    Pages: 106-110
    Received: Apr. 22, 2021
    Accepted: May 31, 2021
    Published: Jun. 07, 2021
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    Abstract: Introduction: HER2/neu (c-erbB-2) is an oncogene that encodes a transmembrane glycoprotein with tyrosine kinase activity known as 185 kDa. This 185 kDa belongs to the epidermal growth factor receptor. Though HER-2 expression has been extensively found in advanced gastric cancer, few recent studies have evaluated the same in early gastric cancers. H... Show More
  • Pathosphysiology of Chronic Myeloid Leukemia, Prognistic Factors and Emerging Treatment Options in a Low Resource Economy

    Patrick Olanrewaju Osho, Okunnuga Ndidi, Ojo Matilda, Odunlade Olufunke

    Issue: Volume 9, Issue 2, June 2021
    Pages: 111-121
    Received: Apr. 21, 2021
    Accepted: May 17, 2021
    Published: Jun. 25, 2021
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    Abstract: Chronic myeloid leukemia (CML) is a triphasic clonal myeloproliferative disorder characterized by the presence of Philadelphi a chromosome (Ph) in over 95% of cases alongside excessive accumulation of clonal myeloid cells in hematopoietic tissues. This occurs as a result of reciprocal translocation between the long arms of chromosome 9 and 22 t (9;... Show More
  • The Landscape of Checkpoint Inhibition in the Management of Hematological Malignancies

    Shukaib Arslan, Alex Herrera, Monzr Al Malki

    Issue: Volume 9, Issue 2, June 2021
    Pages: 122-130
    Received: May 25, 2021
    Accepted: Jun. 08, 2021
    Published: Jun. 30, 2021
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    Abstract: The programmed-death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) pathways are inhibitory immune checkpoints involved in the escape of cancer cells from the immune system. Inhibition of these immune checkpoints can lead to the induction of body’s immune response to these cancer cells. To activate the immune system against the t... Show More